Chromatographic resolution of racemic amines,carboxylic acids,and alcohols by a new homochiral reagent derived fromendo-borneol |
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| Authors: | M R Banks J I G Cadogan I M Dawson I Gosney K J Grant S Gaur P K G Hodgson D E Stevenson |
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| Institution: | (1) Department of Chemistry, University of Edinburgh, West Mains Road, EH9 3JJ Edinburgh, Scotland;(2) Sunbury Research Centre, BP International Ltd., Chertsey Road, TW16 7LN Sunbury-on-Thames, Middlesex, England |
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| Abstract: | Summary Chromatographic separation of racemic amines, carboxylic acids and alcohols can be achieved with excellent resolution as measured in terms of the chromatographic separation factor  by derivatization with a homochiral oxazolidin-2-one easily prepared in three steps fromendo-borneol. The resolved materials can be isolated in excellent yields by cleavage of the resultant diastereomers using conventional methods, which also allow recovery of the chiral resolving agent for re-use. |
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| Keywords: | Column liquid chromatography Diastereomer separation Chiral derivatizing agent Chiral oxazolidin-2-one |
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