Metal‐Free Oxidative Radical Addition of Carbonyl Compounds to α,α‐Diaryl Allylic Alcohols: Synthesis of Highly Functionalized Ketones |
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| Authors: | Xue‐Qiang Chu Hua Meng You Zi Prof?Dr Xiao‐Ping Xu Prof?Dr Shun‐Jun Ji |
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| Institution: | Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123 (China) |
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| Abstract: | A metal‐free direct alkylation of simple carbonyl compounds (ketones, esters, and amides) with α,α‐diaryl allylic alcohols is described. The protocol provides facile access to highly functionalized dicarbonyl ketones by a radical addition/1,2‐aryl migration cascade. The regioselectivity of the reaction was precisely controlled by the nature of the carbonyl compound. |
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| Keywords: | allylic compounds 1 2‐aryl migration dicarbonyl compounds domino reactions radical reactions |
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