Dye Sensitization Offers a Brighter Afterglow Nanoparticle Future for in vivo Recharged Luminescent Imaging |
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Authors: | Juanjuan Zhou Dr Kai Huang Shaochen Lin Nan Zhang Xin Wang Dr Yang Li Prof Zhanjun Li Prof Gang Han |
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Institution: | 1. The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan, Guangdong, 511500 P. R. China;2. Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Medical School, Worcester, Massachusetts, 01605 USA |
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Abstract: | While concerns about improving recharged afterglow intensity in vivo still motivate further exploration, afterglow nanoparticles (AGNP) offer unique optical merit for autofluorescence-free biological imaging. Apart from efforts enhancing the afterglow emission properties of AGNP, improving afterglow excitation response to visible or near infrared light is important but has lacked success. Dye sensitization has been used to improve the optical response of photovoltaic nanomaterials and to enhance upconversion luminescence efficiency. This concept has recently been expanded and applied to AGNPs. As a new multifunctional nanoprobe, such dye-sensitized AGNP takes advantage of both high spatial resolution fluorescence imaging and sensitive afterglow imaging. This Concept introduces the background, the concept, mechanism, and related imaging application, as well as reviewing existing challenges and proposing future developmental directions for the dye-sensitized AGNPs. |
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Keywords: | afterglow dye sensitization imaging multi-model persistent luminescence |
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