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Dynamic Amino Acid Side-Chains Grafting on Folded Peptide Backbone** |
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| Authors: | Dr Benjamin Zagiel Dr Taleen Peker Dr Rodrigue Marquant Guillaume Cazals Gabrielle Webb Dr Emeric Miclet Dr Claudia Bich Dr Emmanuelle Sachon Dr Roba Moumné |
| Institution: | 1. Sorbonne Université, École normale supérieure, PSL University, CNRS, Laboratoire des biomolécules, LBM, 75005 Paris, France
These authors contributed equally.;2. Sorbonne Université, École normale supérieure, PSL University, CNRS, Laboratoire des biomolécules, LBM, 75005 Paris, France;3. UMR 5247-CNRS-UM-ENSCM, Institut des Biomolécules Max Mousseron (IBMM), Université de Montpellier, 34293 Montpellier, France |
| Abstract: | An efficient strategy for the synthesis of large libraries of conformationally defined peptides is reported, using dynamic combinatorial chemistry as a tool to graft amino acid side chains on a well-ordered 3D (3-dimension) peptide backbone. Combining rationally designed scaffolds with combinatorial side chains selection represents an alternative method to access peptide libraries for structures that are not genetically encodable. This method would allow a breakthrough for the discovery of protein mimetic for unconventional targets for which little is known. |
| Keywords: | dynamic combinatorial chemistry peptide library scaffold grafting |