Validity of Inorganic Nanosheets as an Efficient Planar Substituent To Enhance the Enantioselectivity of Transition‐Metal‐Catalyzed Asymmetric Synthesis |
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| Authors: | Li‐Wei Zhao Hui‐Min Shi Zhe An Jiu‐Zhao Wang Prof Jing He |
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| Institution: | State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Box 98, 15 Beisanhuan Dong Lu, Beijing 100029 (P.R. China), Fax: (+86)?10‐64425385 |
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| Abstract: | Effectively enhancing the enantioselectivity is a persistent challenge in heterogeneous asymmetric catalysis. Here, the validity of a layered double hydroxides (LDH) nanosheet as an efficient planar substituent to enhance the enantioselectivity has been investigated theoretically; first in vanadium‐catalyzed asymmetric epoxidation of allylic alcohols, and then in zinc‐catalyzed direct asymmetric aldol addition. The computational predication is further confirmed experimentally in zinc‐catalyzed direct asymmetric aldol addition by controlling the location of catalytic sites. |
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| Keywords: | asymmetric catalysis density functional calculations enantioselectivity heterogeneous catalysis nanosheets |
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