Flow Technology for the Genesis and Use of (Highly) Reactive Organometallic Reagents |
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Authors: | Marco Colella Prof Dr Aichiiro Nagaki Prof Dr Renzo Luisi |
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Institution: | 1. Department of Pharmacy—Drug Sciences, Flow Chemistry and Microreactor Technology FLAME-Lab, University of Bari “A. Moro”, Via E. Orabona 4, Bari, 70125 Italy;2. Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510 Japan |
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Abstract: | In the field of organic synthesis, the advent of flow chemistry and flow microreactor technology represented a tremendous novelty in the way of thinking and performing chemical reactions, opening the doors to poorly explored or even impossible transformations using batch methods. In this Concept article, we would like to highlight the impact of flow chemistry for exploiting highly reactive organometallic reagents, and how, alongside the well-known advantages concerning safety, scalability, and productivity, flow chemistry makes possible processes that are impossible to control by using the traditional batch approach. |
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Keywords: | flash chemistry flow chemistry organometallics synthesis unstable intermediates |
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