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Extracellular Matrix Proteins Involved in Alzheimer's Disease |
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| Authors: | Dr Jun Ma Chao Ma Dr Jingjing Li Dr Yao Sun Prof Fangfu Ye Prof Kai Liu Prof Hongjie Zhang |
| Institution: | 1. Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, 325001 P.R. China
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 P.R. China;2. School of Engineering and Applied Sciences & Department of Physics, Harvard University, 29 Oxford Street, Cambridge, MA, 02138 USA;3. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 P.R. China;4. Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, 325001 P.R. China;5. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 P.R. China Department of Chemistry, Tsinghua University, Beijing, 100084 P.R. China |
| Abstract: | Alzheimer's disease (AD) is one of the most common neurodegenerative diseases and characterized by cognitive and memory impairments. Emerging evidence suggests that the extracellular matrix (ECM) in the brain plays an important role in the etiology of AD. It has been detected that the levels of ECM proteins have changed in the brains of AD patients and animal models. Some ECM components, for example, elastin and heparan sulfate proteoglycans, are considered to promote the upregulation of extracellular amyloid-beta (Aβ) proteins. In addition, collagen VI and laminin are shown to have interactions with Aβ peptides, which might lead to the clearance of those peptides. Thus, ECM proteins are involved in both amyloidosis and neuroprotection in the AD process. However, the molecular mechanism of neuronal ECM proteins on the pathophysiology of AD remains elusive. More investigation of ECM proteins with AD pathogenesis is needed, and this may lead to novel therapeutic strategies and biomarkers for AD. |
| Keywords: | aggregation Alzheimer's disease extracellular matrix pathology protein expression |