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Dinuclear Gold(I) Pyrrolidinedithiocarbamato Complex: Cytotoxic and Antimigratory Activities on Cancer Cells and the Use of Metal–Organic Framework |
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| Authors: | Prof?Dr Raymond Wai‐Yin Sun Ming Zhang Prof?Dr Dan Li Zhi‐Feng Zhang Hong Cai Mian Li Yue‐Jiao Xian Prof?Dr Seik Weng Ng Prof?Dr Alice Sze‐Tsai Wong |
| Institution: | 1. Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, 243?Da Xue Road, Shantou, Guangdong 515063 (P. R. China);2. Department of Chemistry, University of Malaya, 50603 Kuala Lumpur (Malaysia);3. Chemistry Department, King Abdulaziz University, 80203 Jeddah (Saudi Arabia);4. School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong (P. R. China) |
| Abstract: | A dinuclear gold(I) pyrrolidinedithiocarbamato complex ( 1 ) with a bidentate carbene ligand has been constructed and shows potent in vitro cytotoxic activities towards cisplatin‐resistant ovarian cancer cells A2780cis. Its rigid scaffold enables a zinc(II)‐based metal–organic framework (Zn‐MOF) to be used as a carrier in facilitating the uptake and release of 1 in solutions. Instead of using a conventional dialysis approach for the drug‐release testing, in this study, a set of transwell assay‐based experiments have been designed and employed to examine the cytotoxic and antimigratory activities of 1 @Zn‐MOF towards A2780cis. |
| Keywords: | cancer carbenes dithiocarbamate gold metal– organic frameworks |