Chemoselective Chromium(II)‐Catalyzed Cross‐Coupling Reactions of Dichlorinated Heteroaromatics with Functionalized Aryl Grignard Reagents |
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| Authors: | Dr Andreas K Steib Dr Olesya M Kuzmina Sarah Fernandez Dr Sushant Malhotra Prof Paul Knochel |
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| Institution: | 1. Department of Chemistry, Ludwig‐Maximilians‐Universit?t, Butenandtstrasse 5–13, 81377 Munich (Germany);2. Discovery Chemistry, Genentech Inc. 1 DNA Way, South San Francisco, California 94080 (USA) |
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| Abstract: | Chromium(II) chloride catalyzes the chemoselective cross‐coupling reaction of dichloropyridines with a range of functionalized (hetero)aromatic Grignard reagents at room temperature. Functional groups, such as esters and acetals, are well tolerated in this transformation. Previously challenging substrates, quinolines and isoquinolines, participate in the selective Cr‐catalyzed cross‐coupling in cyclopentyl methyl ether (CPME) as the solvent. The effective purging of Cr salts is demonstrated by using various solid supports. |
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| Keywords: | chromium cross‐coupling magnesium nitrogen heterocycles |
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