Molecular‐Level Insights into Intrinsic Peroxidase‐Like Activity of Nanocarbon Oxides |
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Authors: | Dr Ruisheng Zhao Prof Dr Xiang Zhao Prof Dr Xingfa Gao |
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Institution: | 1. Institute for Chemical Physics and Department of Chemistry, State Key Laboratory of Electrical Insulation and Power Equipment, Xi'an Jiaotong University, Xi'an 710049 (P. R. China);2. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Science, Beijing 100049 (P. R. China) |
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Abstract: | Nanocarbon oxides have been proved to possess great peroxidase‐like activity, catalyzing the oxidation of many peroxidase substrates, such as 3,3′,5,5′‐tetramethylbenzidine (TMB) and o‐phenylenediamine dihydrochloride (OPD), accompanied by a significant color change. This chromogenic reaction is widely used to detect glucose and occult blood. The chromogenic reaction was intensively investigated with density functional theory and molecular‐level insights into the nature of peroxidase‐like activity were gained. A radical mechanism was unraveled and the carboxyl groups of nanocarbon oxides were identified as the reactive sites. Aromatic domains connected with the carboxyl groups were critical to the peroxidase‐like activity. |
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Keywords: | carboxyl density functional calculations nanocarbon oxides peroxidase reaction mechanism |
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