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Intramolecular trans‐Dicarbofunctionalization of Alkynes by a Formal anti‐Carbopalladation/Stille Cascade |
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| Authors: | Bastian Milde Andreas Reding Finn J Geffers Prof Dr Peter G Jones Prof Dr Daniel B Werz |
| Institution: | 1. Technische Universit?t Braunschweig, Institute of Organic Chemistry, Braunschweig, Germany;2. Technische Universit?t Braunschweig, Institute of Inorganic and Analytical Chemistry, Braunschweig, Germany |
| Abstract: | An intramolecular Pd‐catalyzed trans‐dicarbofunctionalization of internal alkynes using aryl bromides and aryl stannanes is presented. Tetrasubstituted double bonds embedded in an oligocyclic ring system are obtained in a regio‐ and diastereoselective fashion. The transformation features a broad substrate scope and functional‐group tolerance. |
| Keywords: | alkynes carbopalladation dicarbo functionalization domino reaction Stille reaction |