Silver(I)‐Catalyzed Enantioselective [3+2]‐Cycloaddition Reaction of α‐Silylimines: A Facile Route to Quaternary‐Carbon‐Rich Scaffolds |
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| Authors: | Dr Naredla Kesava‐Reddy Christopher Golz Prof?Dr Carsten Strohmann Dr Kamal Kumar |
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| Institution: | 1. Abteilung Chemische Biologie, Max-Planck-Institut für Molekulare Physiologie, Dortmund, Germany;2. Fakult?t Chemie und Chemische Biologie, Technische Universit?t Dortmund, Dortmund, Germany |
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| Abstract: | A silver‐catalyzed highly enantioselective 1,3‐dipolar cycloaddition reaction of α‐silylimines with pyrone‐based trisubstituted olefins was developed affording bi‐ and tricyclic α‐quaternary‐carbon‐rich pyrano‐pyrrolidines in excellent yields. The tricyclic benzopyrone adducts thus obtained were efficiently transformed into highly complex tetracyclic scaffolds supporting four consecutive stereogenic centers with three quaternary carbons. |
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| Keywords: | asymmetric catalysis azomethine ylides cycloaddition quaternary carbons α -silyl imines |
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