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Copper‐Catalyzed Reaction Cascade of Thiophenol Hydroxylation and S‐Arylation through Disulfide‐Directed C−H Activation |
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| Authors: | Prof?Dr Dawei Wang Xin Yu Wei Yao Wenkang Hu Chenyang Ge Prof?Dr Xiaodong Shi |
| Institution: | 1. The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi, China;2. Department of Chemistry, University of South Florida, Tampa, FL, USA |
| Abstract: | Copper‐catalyzed thiophenol C?H activation is described. Through an initial attempt to conduct C‐arylation with arylboronic acid, a rather surprising sequential C?H activation and S‐arylation was discovered. Mechanistic investigation revealed the disulfide intermediate as the key component in directing C?H oxidation. The overall reaction proceeded under mild conditions with molecular oxygen as the oxidant. Discovery of disulfide as the directing group provides a potential new direction for catalytic C?H functionalization under mild conditions. |
| Keywords: | C− H activation disulfide homogeneous catalysis hydroxylation S-arylation |