Comparative analyses of a family of potential self-replicators: the subtle interplay between molecular structure and the efficacy of self-replication |
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Authors: | Pearson Russell J Kassianidis Eleftherios Slawin Alexandra M Z Philp Douglas |
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Institution: | Centre for Biomolecular Sciences, School of Chemistry, University of St Andrews, North Haugh, St Andrews KY16 9ST, UK. |
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Abstract: | It is envisioned that protocols based on self-replication will emerge as a formidable synthetic apparatus for the production of nanoscale assemblies through molecular structures that are capable of automultiplication with high reaction rates and selectivities. To achieve this goal, a complete understanding of the relationship between molecular structure and replication efficiency is necessary. Rigorous experimental and theoretical analyses of a series of self-complementary scaffolds that are intimately related in a constitutional sense, manufactured through the Diels-Alder reaction of complementary subunits, were undertaken. Experimental and computational methods were employed to map the key determinants that dictate the emergence of self-replicative function, as well as the efficiency, rate and selectivity of the self-replicative processes. |
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Keywords: | kinetics molecular recognition recognition‐mediated reactions self‐replication supramolecular chemistry |
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