Molecular Recognition of Nucleotides in Water by Scorpiand‐Type Receptors Based on Nucleobase Discrimination |
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Authors: | Mario Inclán Dr M Teresa Albelda Dr Esther Carbonell Dr Salvador Blasco Antonio Bauzá Prof Antonio Frontera Prof Enrique García‐España |
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Institution: | 1. Molecular Science Institute (ICMol), Universitat de València, C/Catedrático José Beltrán 2, 46980 Paterna (Spain);2. GIBI230, Grupo de Investigación Biomédica en Imagen, IIS La Fe, Valencia (Spain);3. Departament de Química, Universitat de les Illes Balears, 07122 Palma de Mallorca (Spain) |
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Abstract: | The detection of nucleotides is of crucial importance because they are the basic building blocks of nucleic acids. Scorpiand‐based polyamine receptors functionalized with pyridine or anthracene units are able to form stable complexes with nucleotides in water, based on coulombic, π–π stacking, and hydrogen‐bonding interactions. This behavior has been rationalized by means of an exploration with NMR spectroscopy and DFT calculations. Binding constants were determined by potentiometry. Fluorescence spectroscopy studies have revealed the potential of these receptors as sensors to effectively and selectively distinguish guanosine‐5′‐triphosphate (GTP) from adenosine‐5′‐triphosphate (ATP). |
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Keywords: | molecular recognition nucleotides scorpiands sensors supramolecular chemistry |
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