Base‐Mediated Syntheses of Di‐ and Trisubstituted Imidazoles from Amidine Hydrochlorides and Bromoacetylenes |
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| Authors: | Dr Xiao Yun Chen Prof?Dr Ulli Englert Prof?Dr Carsten Bolm |
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| Institution: | 1. Institut für Organische Chemie, RWTH Aachen University, Landoltweg 1, 52074 Aachen (Germany);2. Institut für Anorganische Chemie, RWTH Aachen University, Landoltweg 1, 52074 Aachen (Germany) |
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| Abstract: | A new transition metal‐free method for the preparation of substituted imidazoles from easy‐to‐handle amidine hydrochlorides and bromoacetylenes has been developed. The reactions proceed in air and use inexpensive K2CO3 as base. Additions of 2,2′‐bipyridine and water have beneficial effects on the product yields. Various di‐ and trisubstituted imidazoles have been prepared in good yields (up to 88 %). |
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| Keywords: | alkynes amidines base heterocycles imidazoles |
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