Circularly Polarized Light Triggers Biosensing Based on Chiral Assemblies |
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| Authors: | Dr Changlong Hao Prof Liguang Xu Prof Maozhong Sun Hongyu Zhang Prof Hua Kuang Prof Chuanlai Xu |
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| Institution: | International Joint Research Laboratory for Biointerface and Biodetection, State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122 P. R. China |
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| Abstract: | Chiral assemblies have attracted great interest because of their many potential applications, such as in chiral sensing, asymmetric catalysis, and optical devices. Here, by using specific DNAzymes, a chiral core–satellite assembly consisting of a DNAzyme-driven spiny nanorod dimer core and upconversion nanoparticle (UCNP) satellite was constructed. The chirality of this assembly originates from the geometry chirality. This chiral assembly can be used as a photothermally activated probe for the simultaneous detection of multiple analytes in living cells. Under illumination with 980 nm left circularly polarized (LCP) light, this probe was used to quantify and visualize intracellular metal ions. |
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| Keywords: | chiral assemblies circularly polarized light detection DNAzymes metal ions |
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