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“Turn-On” Activatable AIE Dots for Tumor Hypoxia Imaging |
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| Authors: | Tianhao Xue Xiangqian Jia Jilei Wang Jingyuan Xiang Wei Wang Dr Juanjuan Du Dr Yaning He |
| Institution: | 1. Department of Chemical Engineering, Key Laboratory of Advanced Materials (MOE), Tsinghua University, Beijing, 100084 China
These authors contributed equally to this work.;2. School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084 China These authors contributed equally to this work.;3. Department of Chemical Engineering, Key Laboratory of Advanced Materials (MOE), Tsinghua University, Beijing, 100084 China;4. School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084 China |
| Abstract: | A hypoxia-responsive fluorescence probe of amphiphilic PEGylated azobenzene caged tetraphenylethene (TPE) for tumor cell imaging is reported; it possesses excellent solubility in aqueous medium due to the easy formation of micelles by self-assembly. The fluorescence resonance energy transfer (FRET) process ensures that the fluorescence of the azobenene caged AIE fluorogen is quenched efficiently. When cultured with tumor cells, the azo-bond is reduced under hypoxia conditions and the fluorescence of AIE fluorogen recovers dramatically. Besides using UV light, NIR light can also be used as the excited light resource to generate the fluorescence due to the two-photon fluorescence imaging process. |
| Keywords: | AIE azobenzene fluorescence probe hypoxia self-assembly |