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XANES/EPR Evidence of the Oxidation of Nickel(II) Quinolinylpropioamide and Its Application in Csp3−H Functionalization |
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| Authors: | Dr Wenyan Hao Yuchen Sha Dr Yi Deng Yi Luo Li Zeng Shan Tang Dr Yue Weng Prof Dr Chien-Wei Chiang Prof Dr Aiwen Lei |
| Institution: | 1. National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang, 330022 P.R. China
These authors contributed equally to this work.;2. College of Chemistry and Molecular Sciences, Institute for Advanced Studies (IAS), Wuhan University, Wuhan, 430072 P.R. China These authors contributed equally to this work.;3. College of Chemistry and Molecular Sciences, Institute for Advanced Studies (IAS), Wuhan University, Wuhan, 430072 P.R. China;4. College of Chemistry and Molecular Sciences, Institute for Advanced Studies (IAS), Wuhan University, Wuhan, 430072 P.R. China National Synchrotron Radiation Research Center (NSRRC), Hsinchu Science Park, Hsinchu, Taiwan;5. National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang, 330022 P.R. China |
| Abstract: | An in situ generated oxidation species of nickel quinolinylpropioamide intermediate was produced. Characterization by X-ray absorption near edge structure (XANES) and EPR provides complementary insights into this oxidized nickel species. With aliphatic amides and isocyanides as substrates, a nickel-catalyzed facile synthesis of structurally diverse five-membered lactams could be achieved. |
| Keywords: | Csp3−H functionalization EPR spectroscopy Ni catalyst NiIII species X-ray absorption spectroscopy |