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Synthesis of Highly Functionalized N,N-Diarylamides by an Anodic C,N-Coupling Reaction |
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| Authors: | Maurice Dörr Sebastian Lips Prof?Dr Carlos Alberto Martínez-Huitle Dr Dieter Schollmeyer Prof?Dr Robert Franke Prof?Dr Siegfried R Waldvogel |
| Institution: | 1. Institut für Organische Chemie, Johannes Gutenberg-Universität Mainz, Duesbergweg 10–14, 55128 Mainz, Germany;2. Institut für Organische Chemie, Johannes Gutenberg-Universität Mainz, Duesbergweg 10–14, 55128 Mainz, Germany
Instituto de Química, Avenida Senador Salgado Filho, Universidade Federal do Rio Grande do Norte, 3000 Campus Universitario, Lagoa Nova, Natal, 5907800, RN Brazil;3. Evonik Performance Materials GmbH, Paul-Baumann-Straße 1, 45772 Marl, Germany Lehrstuhl für Theoretische Chemie, Ruhr-Universität Bochum, 44780 Bochum, Germany |
| Abstract: | We report an innovative, sustainable and straightforward protocol for the synthesis of N,N-diarylamides equipped with nonprotected hydroxyl groups by using electrosynthesis. The concept allows the application of various substrates furnishing diarylamides with yields up to 57 % within a single and direct electrolytic protocol. The method is thereby easy to conduct in an undivided cell with constant current conditions offering a versatile and short-cut alternative to conventional pathways. |
| Keywords: | C N-coupling C?H activation electrochemistry oxidation sustainable chemistry |