Intramolecular Hydroamination of Selenoalkynes to 2-Selenylindoles in the Absence of Catalyst |
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| Authors: | Dr Felipe L Coelho Eduarda S Gil Dr Paulo F B Gonçalves Dr Leandra F Campo Dr Paulo H Schneider |
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| Institution: | Instituto de Química, Universidade Federal do Rio Grande do Sul (UFRGS), PO Box 15003, 91501-970 Porto Alegre, RS, Brazil |
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| Abstract: | In this work, a series of 2-chalcogenylindoles was synthesized by an efficient methodology, starting from chalcogenoalkynes, including a previously unreported tellurium indole derivative. For the first time, these 2-substituted chalcogenylindoles were obtained in the absence of metal catalyst or base, under thermal conditions only. In addition, the results described herein represent a methodology with inverse regioselectivity for the chalcogen functionalization of indoles. |
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| Keywords: | chalcogenoalkynes density functional calculations indoles selenium thermal cyclisation |
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