Stereoselective Insertion of Benzynes into Lawsones: Synthesis of Biologically Important Benzannulated Bicyclo[3.3.0]octanes |
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Authors: | Dr A Suresh Kumar Dr Guguloth Thirupathi G Surendra Reddy Prof Dr Dhevalapally B Ramachary |
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Institution: | Catalysis Laboratory, School of Chemistry, University of Hyderabad, Hyderabad-, 500 046 India |
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Abstract: | An ideal stereoselective insertion of in situ generated benzynes into lawsones through domino formal 2+2]-cycloaddition followed by rearrangement is disclosed. The reaction allowed for the preparation of biologically important benzannulated bicyclo3.3.0]octanes in good yields and with excellent selectivities by using simple substrates and conditions. |
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Keywords: | arynes bicyclo[3 3 0]octanes catalysis [3+2]-cycloaddition lawsones |
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