| Institution: | 1. Fluorescent Chemistry Lab, Department of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, 226031 India;2. Endocrinology Division, CSRI-Central Drug Research Institute, Lucknow, 226031 India;3. Fluorescent Chemistry Lab, Department of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, 226031 India
Academy of Scientific and Innovative Research, Ghaziabad, 201002 India |
| Abstract: | A new dual responsive “turn-on” and “ratiometric” aggregation-induced emission luminogen (AIEgen) 3-formyl-5-(piperidin-1-yl)biphenyl-4-carbonitrile 6 a (FPBC 6 a ) for selective detection of hydrazine in solution as well as in vapour phase is described. At a low concentration of 2.5 μm , the probe FPBC 6 a is non-fluorescent (turn-off) but remarkably lights up (turn-on with blue emission) in the presence of hydrazine solution (0.25–25 μm ). Interestingly, at higher concentrations, the nanoaggregates of FPBC 6 a (>25 μm , 99 % HEPES in DMSO) displayed ratiometric response in the presence of hydrazine with a remarkable hypsochromic shift from the green (500–550 nm) to blue regions (440–480 nm). Furthermore, a real application of FPBC 6 a was successfully demonstrated through the detection and visualization of hydrazine in live cervical cancer cells as well as using portable test strips. |
