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Catalytic Generation and Chemoselective Transfer of Nucleophilic Hydrides from Dihydrogen |
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| Authors: | Dr Felix Pape Lea T Brechmann Jun-Prof Dr Johannes F Teichert |
| Institution: | 1. Institut für Chemie, Technische Universität Berlin, Strasse des 17. Juni 115, 10623 Berlin, Germany;2. Institut für Chemie, Technische Universität Berlin, Strasse des 17. Juni 115, 10623 Berlin, Germany
These authors contributed equally to this work. |
| Abstract: | Copper(I)–N-heterocyclic-carbene (NHC) complexes enabled the catalytic generation of nucleophilic hydrides from dihydrogen (H2) and their subsequent transfer to allylic chlorides. The highly chemoselective catalyst displayed no concomitant hydrogenation reactivity; in fact, the terminal double bond formed in the hydride transfer remained intact. Switching to deuterium gas (D2) allowed for regioselective monodeuteration with excellent isotope incorporation. |
| Keywords: | catalysis copper deuterium hydride hydrogen |