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Surface-Active Fluorinated Quantum Dots for Enhanced Cellular Uptake
Authors:Pablo G Argudo  Dr Mónica Carril  Prof?Dr María T Martín-Romero  Dr Juan J Giner-Casares  Dr Carolina Carrillo-Carrión
Institution:1. Institute of Fine Chemistry and Nanochemistry, Department of Physical Chemistry and Applied Thermodynamics, University of Córdoba, Campus de Rabanales, Edificio Marie Curie, 14014 Córdoba, Spain;2. Biofisika Institute (CSIC, UPV/EHU) and Department of Biochemistry and Molecular Biology, University of the Basque Country UPV/EHU, Barrio Sarriena s/n, 48940 Leioa, Spain

Ikerbasque, Basque Foundation for Science, Maria Diaz de Haro 3,6 solaiura, 48011 Bilbao, Spain;3. Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Paseo Miramón 182, 20014 San Sebastian, Spain

Abstract:Fluorescent nanoparticles, such as quantum dots, hold great potential for biomedical applications, mainly sensing and bioimaging. However, the inefficient cell uptake of some nanoparticles hampers their application in clinical practice. Here, the effect of the modification of the quantum dot surface with fluorinated ligands to increase their surface activity and, thus, enhance their cellular uptake was explored.
Keywords:cell uptake  fluorine  Langmuir monolayer  quantum dots  surface activity
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