Ni-Catalyzed Regioselective Hydroarylation of 1-Aryl-1,3-Butadienes with Aryl Halides |
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| Authors: | Chengdong Wang Yingjie Guo Prof?Dr Xiaoming Wang Dr Zheng Wang Prof Kuiling Ding |
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| Institution: | 1. Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Frontier Science Center for Transformative Molecules School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240 China;2. State Key Laboratory of Organometallic Chemistry Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032 China |
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| Abstract: | An efficient nickel-catalyzed regioselective hydroarylation of 1,3-dienes with aryl halides and a silane has been developed, affording a range of allylic arenes in good to excellent yields under mild conditions. This method exhibits broad substrate scope, and excellent functional group tolerance. Late-stage modification of complex architectures was demonstrated. |
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| Keywords: | aryl halide coupling reactions hydroarylation nickel 1 3-dienes |
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