血脑屏障通透性增效方法的研究进展

血脑屏障作为脑部的屏障系统,具有较强的保护作用,维持着中枢神经系统的内环境的稳定,同时也阻止药物进入脑部治疗中枢神经系统疾病。多年来,在提高血脑屏障通透性的研究方面有了很大进展,让药物靶向入脑,为治疗中枢神经系统疾病提供了很大的帮助。本文系统介绍血脑屏障的结构,其中主要介绍产生血脑屏障的解剖和功能结构,并对提高其通透性的增效方法和机制进行了概括,主要从物理、化学、生物学和纳米给药载体等方面阐述了提高血脑屏障透过方式,并简要介绍了一些具体药物的输送的应用。

Research progress in methods of improving blood brain barrier permeability

The Blood Brain Barrier (BBB) as a brain barrier system is crucial in protecting the brain and is essential for maintaining their bathing microenvironment. This makes it difficult to deliver beneficial drugs across the BBB to treat CNS(Central Nervous System) diseases. Great progress has been made in research efforts in improving the BBB permeability in recent years, thus providing a lot of help to delivery drug to the targeted brain part and to treat CNS diseases. This paper comprehensively discusses the anatomical and functional structures of the BBB and summarizes the methods and mechanisms of increasing BBB permeability. It also elaborates on the physics, chemistry, biology and nanocarrier aspects to improve drug delivery to the brain, and introduces some specific drug delivery.