| 制备温度对硫辛酸脂质纳米粒的影响 |
| |
| 引用本文： | 邹爱华,郑锴,杨晓敏,夏强.制备温度对硫辛酸脂质纳米粒的影响[J].化学通报,2012(6):519-525. |
| |
| 作者姓名： | 邹爱华 郑锴 杨晓敏 夏强 |
| |
| 作者单位： | 华东理工大学生物反应器工程国家重点实验室;东南大学生物科学与医学工程学院;东南大学苏州市生物医用材料与技术重点实验室 |
| |
| 基金项目： | 科技部国际合作重大项目(2008DFB50060);教育部博士点新教师基金项目(200802511024);国家自然科学青年基金项目(21003047)资助 |
| |
| 摘 要： | 通过脂质和乳化剂筛选实验得到适合于硫辛酸(ALA)负载的脂质基体和乳化剂,在此基础上分别在55℃和65℃下用高压均质法(HPH)制备了硫辛酸脂质纳米粒(ALA-NLC)。通过高效液相色谱(HPLC)、动态光散射(DLS)、原子力显微镜(AFM)、微差示扫描量热(micro-DSC)研究制备温度和保存时间对ALA-NLC性质如ALA的负载量、粒径、稳定性及形貌的影响。结果表明,制备温度和保存时间对粒径、zeta电位及ALA负载量均有较大影响。Micro-DSC结果表明,55℃和65℃下制备的ALA-NLC都可能存在过冷态现象,但是55℃制备的样品更稳定,所得配方在ALA膳食补给上具有潜在的应用价值。
|
| 关 键 词： | 脂质纳米粒 硫辛酸 抗氧化膳食补给 |
Effect of Preparation Temperature on the α-Lipoic Acid Loaded Nanostructured Lipid Carriers(ALA-NLC) |
| |
| Zou Aihua,Zheng Kai,Yang Xiaomin,Xia Qiang.Effect of Preparation Temperature on the α-Lipoic Acid Loaded Nanostructured Lipid Carriers(ALA-NLC)[J].Chemistry,2012(6):519-525. |
| |
| Authors: | Zou Aihua Zheng Kai Yang Xiaomin Xia Qiang |
| |
| Institution: | 2,3(1Institute of Applied Chemistry,East China University of Science and Technology,Shanghai 200237; 2 School of Biological Science & Medical Engineering,Southeast University,Nanjing 210096; 3Suzhou Key Laboratory of Biomedical Materials and Technology,Southeast University,Suzhou 215123) |
| |
| Abstract: | The lipid and emulsifier of α-lipoic acid loaded nanostructured lipid carriers(ALA-NLC) were obtained by screening.ALA-NLC was prepared at two temperatures(55℃ and 65℃) by high pressure homogenization(HPH) method.The ALA load amount,particle size,stability,and morphology of the samples were investigated by HPLC,dynamic light scattering(DLS),AFM and micro-differential scanning calorimeter(micro-DSC).The effects of storage time and preparation temperature on the particle size,zeta potential and ALA load amount of ALA-NLC were analyzed statistically.Micro-DSC results showed that 55℃ was more appropriate than 65 ℃ for ALA-NLC preparation.However,supercooled melts might occur in ALA-NLC dispersions.The presented formulations have the potential application for ALA dietary supplement. |
| |
| Keywords: | Nanostructured lipid carriers α-Lipoic acid Antioxidant dietary supplement |
| 本文献已被 CNKI 等数据库收录！ |
|
