合成源1,4-萘醌类化合物抑菌活性研究进展

1,4-萘醌作为广泛存在的一种物质，其生物活性尤其是抗菌作用受到越来越多的关注。本文对不同取代类型的合成源1,4-萘醌衍生物进行总结，并探讨其抑菌活性及构效关系，发现在1,4-萘醌的2位引入含氨基取代、含硫取代的基团能够提高抗菌活性，且通常含硫取代比氨基取代基团的抗菌活性高。期望本文能为1,4-萘醌类抗菌药物的研发提供参考。

Research Progress in Antibacterial Activities of Synthetic 1,4-Naphthoquinone Compounds

1,4-Naphthoquinone is a widely existing substance, and its biological activity has attracted more and more attention, especially in antibacterial aspects. This article summarizes the synthetic 1,4-naphthoquinone derivatives of different substitution types, and discusses their antibacterial activities and structure-activity relationship. It is found that the introduction of amino-substituted and sulfur-containing substitutions at 2-position of 1,4-naphthoquinone can improve the antibacterial activity, and the antibacterial activity of the sulfur-containing substitution is generally higher than that of the amino substitution group. It is hoped that this article can provide a reference for the future research and development of 1,4-naphthoquinone antibacterial drugs.