| 甲基苯丙胺标准物质的定值与不确定度分析 |
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| 引用本文： | 张盼,苏福海,王海峰,李红梅,杨晶.甲基苯丙胺标准物质的定值与不确定度分析[J].化学通报,2012(4):372-375. |
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| 作者姓名： | 张盼 苏福海 王海峰 李红梅 杨晶 |
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| 作者单位： | 北京化工大学生命科学与技术学院;中国计量科学研究院化学计量与分析科学研究所 |
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| 基金项目： | 质检公益性行业科研专项(201010011)资助 |
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| 摘 要： | 为了建立法庭科学毒品检测量值溯源体系,研制了甲基苯丙胺纯度标准物质。通过红外光谱、质谱法对甲基苯丙胺样品进行定性分析,优化并建立了高效液相色谱(HPLC)、差示扫描量热法(DSC)两种定值分析方法。采用热重分析法和电感耦合等离子体质谱法测定水分和无机离子的含量。通过均匀性与稳定性检验结果表明,甲基苯丙胺标准物质的均匀性良好,稳定性至少1年,同时对其进行了不确定度评定。研制的甲基苯丙胺标准物质的纯度为99.8%,扩展不确定度为0.2%(k=2)。
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| 关 键 词： | 甲基苯丙胺 标准物质 液相色谱法 差示扫描量热法 不确定度评定 |
The Certification of Methamphetamine Certified Reference Material and its Uncertainty Evaluation |
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| Zhang Pan,Su Fuhai,Wang Haifeng,Li Hongmei,Yang Jing.The Certification of Methamphetamine Certified Reference Material and its Uncertainty Evaluation[J].Chemistry,2012(4):372-375. |
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| Authors: | Zhang Pan Su Fuhai Wang Haifeng Li Hongmei Yang Jing |
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| Institution: | 1(1 College of Life Science and Technology,Beijing University of Chemical Technology,Beijing 100029;2 Division of Chemical Metrology and Analytical Science,National Institute of Metrology of China,Beijing 100013) |
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| Abstract: | In order to establish the traceability system of detection value of drugs in forensic science,methamphetamine was prepared and certified as pure certified reference material(CRM).The structure of the material was qualitatively identified by IR and MS techniques.Then the principal component value was obtained through establishing the methods of HPLC and DSC.The contents of water and inorganic ion were determined by TGA and ICP-MS.Meanwhile,the uncertainty was evaluated.The test results of the homogeneity and stability showed that prepared methamphetamine had good uniformity and was stable at least 1 year,its purity was 99.8% and the expanded uncertainty was 0.2%(k=2). |
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| Keywords: | Methamphetamine Certified Reference Material(CRM) High Performance Liquid Chromatography(HPLC) Differential Scanning Calorimetry(DSC) Uncertainty Evaluation |
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