| 荧光量子点及其在生物检测中的应用 |
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| 引用本文： | 邹函君,曹渊,徐彦芹,甘霖.荧光量子点及其在生物检测中的应用[J].化学通报,2012(3):209-215. |
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| 作者姓名： | 邹函君 曹渊 徐彦芹 甘霖 |
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| 作者单位： | 重庆大学化学化工学院;重庆市肿瘤医院 |
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| 基金项目： | 重庆市科技攻关重点项目(2011GGB108);中央高校基本科研业务费(CDJXS10221136);重庆大学研究生创新基金(201005AIA0010332)资助 |
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| 摘 要： | 量子点(QDs)是一种零维的半导体纳米晶体,与传统的有机染料相比,具有独特的光学特征。由于它们具有激发光谱宽、发射光谱窄、发射波长精确可调、量子产率高和荧光稳定性好等特点,作为新一代的生物荧光探针,已被广泛应用于生物检测。本文介绍了QDs的基本概念和性质,探讨了QDs的制备方法及表面修饰,对其毒性也作了简要分析,提供了QDs在荧光免疫分析、生物芯片、生物传感器及体内成像等方面的应用实例。随着技术发展的不断进展,QDs在生物分析领域有着更为广泛的潜在的应用前景。
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| 关 键 词： | 量子点 荧光探针 生物检测 |
Fluorescent Quantum Dots and their Application in Biological Detection |
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| Zou Hanjun,Cao Yuan,Xu Yanqin,Gan Lin.Fluorescent Quantum Dots and their Application in Biological Detection[J].Chemistry,2012(3):209-215. |
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| Authors: | Zou Hanjun Cao Yuan Xu Yanqin Gan Lin |
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| Institution: | 1 Institute of Chemistry and Chemical Engineering,Chongqing University,Chongqing 400030; 2 Chongqing Cancer Hospital,Chongqing 400030) |
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| Abstract: | Quantum dots(QDs)are zero-dimension semiconductor nanocrystals.Compared to traditional organic dyes,QDs possess unique optical properties.As a new generation of fluorescent probe QDs have been widely used in biological detection due to their broad excitation and narrow emission spectra,accurate size-tunable emission wavelength,high quantum yield and good photostability.The basic concept,properties,the preparation method,surface modification of QDs and their toxicity were introduced,and some examples on QDs-based fluorescence immunoassay,biochips,biosensors and animal imaging in vivo were given out in this paper.As developing QDs technology,QDs will exhibit the great potential in bio-analytical applications. |
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| Keywords: | Quantum dots Fluorescent probe Biological detection |
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