冠状病毒抑制剂的研究进展

冠状病毒是一类广泛存在且对人及家畜具有严重危害的病原体,其中于2003年全球爆发的严重急性呼吸综合征病毒(SARS-CoV)以及2012年被发现并传播的中东呼吸综合征病毒(MERS-CoV)给人们的生命健康以及全球经济造成了严重威胁以及重大损失,特别是2019年末爆发的新型冠状病毒(SARS-CoV-2),截至目前为止已经造成了几百万的感染病例以及几十万人的死亡。可以看出,冠状病毒具有较高的传播性以及较高的致死率,时刻威胁着人们的健康安全,但是针对冠状病毒的感染目前还没有批准上市的有效药物,也没有用于预防的疫苗。本文围绕目前关于冠状病毒的潜在成药性靶点,详细介绍了针对这些靶点的具有代表性的抑制剂的结构设计及其化学合成方法,以期为目前抗冠状病毒药物的研发提供一些参考。

Progress in Development of Coronavirus Inhibitors

Coronaviruses are a kind of widely exist pathogens that could cause serious health hazard to human and multiple species of animals, among them, Severe Acute Respiratory Syndrome virus (SARS-CoV)and Middle East respiratory syndrome (MERS-CoV)were broken out in 2003 and 2012 respectively, both of them cause serious health risk to human and considerable loss to global economy. Especially, the Novel Coronavirus(SARS-CoV-2)which was broken out at the end of 2019 has caused millions of infections and tens of thousands death. It is obviously that coronaviruses are highly contagious infectious virus with high mortality rate, which seriously threaten people''s health and safety. However, there is no effective drug approved for treatment of them and no vaccine for protect people at present. In this review, we introduced the drugs-like target in coronaviruses and the design and synthesis of representative inhibitors of them, hoping to provide some references for the development of effective therapeutic drugs.