| 二茂铁基三烯酮类姜黄素类似物的合成、晶体结构及电化学性质 |
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| 引用本文： | 卢博,陈芳圆,任淑慧,万屏南,李靖聪,欧阳雯婷,林艳,崔汉峰.二茂铁基三烯酮类姜黄素类似物的合成、晶体结构及电化学性质[J].化学通报,2023,86(4):491-494,504. |
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| 作者姓名： | 卢博 陈芳圆 任淑慧 万屏南 李靖聪 欧阳雯婷 林艳 崔汉峰 |
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| 作者单位： | 江西中医药大学 药学院,江西省医药学校 中医药系,江西中医药大学 药学院,江西中医药大学 药学院,江西中医药大学 药学院,江西中医药大学 药学院,江西中医药大学 药学院,江西中医药大学药学院 |
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| 基金项目： | 国家自然科学基金项目(82160729)、江西省教育厅科学技术研究项目(GJJ201226,GJJ190668,GJJ211234)和江西省中医药管理局科技计划项目(2022A379)资助 |
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| 摘 要： | 以不同取代基的肉桂醛和二茂铁为起始原料，经Vilsmeier-Haack甲酰化反应、Claisen-Schmidt等反应合成5种新型二茂铁基三烯酮类姜黄素类似物，其结构经1H NMR、13C NMR和HRMS(ESI-TOF)表征，并用X-ray单晶衍射确定了5d的晶体结构，其构型为反式构型，电化学研究表明化合物5a具有较高氧化还原活性。
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| 关 键 词： | 二茂铁 三烯酮 合成 晶体结构 电化学性质 |
| 收稿时间： | 2022/9/14 0:00:00 |
| 修稿时间： | 2022/10/21 0:00:00 |
Synthesis, crystal structure and electrochemical properties of ferrocene-based trienone curcumin analogues |
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| LU Bo,CHEN Fangyuan,REN Shuhui,WAN Pingnan,LI Jingcong,OUYANG Wenting,LIN Yan and CUI Hanfeng.Synthesis, crystal structure and electrochemical properties of ferrocene-based trienone curcumin analogues[J].Chemistry,2023,86(4):491-494,504. |
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| Authors: | LU Bo CHEN Fangyuan REN Shuhui WAN Pingnan LI Jingcong OUYANG Wenting LIN Yan and CUI Hanfeng |
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| Institution: | School of Pharmacy,Jiangxi University of Chinese Medicine,Department of Chinese Medicine,Jiangxi Pharmaceutical School,School of Pharmacy,Jiangxi University of Chinese Medicine,School of Pharmacy,Jiangxi University of Chinese Medicine,School of Pharmacy,Jiangxi University of Chinese Medicine,School of Pharmacy,Jiangxi University of Chinese Medicine,School of Pharmacy,Jiangxi University of Chinese Medicine, |
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| Abstract: | Five new ferrocene-based trienone curcumin analogues were synthesized in three steps by Vilsmeier-Haack formylation and Claisen-Schmidt reactions using ferrocene as starting material. Their structures were characterized by 1H NMR, 13C NMR and HRMS (ESI-TOF), and the crystal structure of 5d was determined by X-ray single-crystal diffraction, and the conformation was trans. Electrochemical studies showed that compound 5a has high redox activity. |
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| Keywords: | Ferrocene Trienone Synthesis Crystal structure Electrochemical property |
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