基于透明质酸构筑的药物递送载体及其应用

传统纳米药物控释载体主要通过细胞胞吞作用实现药物递送,其主要过程为被动靶向机制,因此会影响纳米载体在肿瘤组织的富集和治疗效果。近年来生物大分子透明质酸因其优异的水溶性、生物相容性、可降解性和肿瘤靶向性备受科研工作者青睐,已被广泛用于药物控释载体的构筑中,并成为靶向肿瘤治疗纳米载体领域的研究热点。本文根据透明质酸基纳米载体治疗机制的不同,从透明质酸基纳米载体在化疗、光热治疗、光动力治疗以及联合治疗的应用方面对其性能进行了总结和评述,并在此基础上展望了未来透明质酸基纳米治疗载体的研究方向和发展趋势。

Hyaluronic Acid-Based Drug Delivery Carriers and Their Applications

Traditional nano-drug delivery carriers always realize drug release through cellular endocytosis process. However, due to their passive targeting mechanism, the enrichment and therapeutic effect of nano carriers in tumor tissues will be reduced. In recent years, hyaluronic acid (HA) has been widely reported by researchers due to its excellent water-solubility, biocompatibility, biodegradability and active tumor targeting properties. Therefore, HA has been widely utilized in the construction of drug delivery carriers and has attracted much more attention in the field of targeted cancer therapy field. Based on the different therapeutic mechanism, HA-based nano carriers and their applications in chemotherapy, photothermal therapy, photodynamic therapy, and synergestic therapy fields are summarized in this paper. On this basis, the research trends are also expected based on the progress of HA-based nano-carriers.