基于生物传感器的内毒素检测研究进展

内毒素是造成内毒素血症、多器官功能衰竭的关键因子,对人体健康存在着严重的危害。发展高选择性、高灵敏度、快捷便携且不受现场限制的检测方法具有重要意义。生物传感器以其高效、灵敏、易于自动化和微型化等优点,在相关检测领域中显示出重要的研究价值和巨大的发展空间。本文简要介绍了近年来内毒素的常用检测方法,重点综述了光学生物传感器和电化学生物传感器在内毒素检测应用中的研究进展。对生物传感器在内毒素检测中面临的挑战及其发展趋势进行了讨论和展望。

Research progress of endotoxin detection based on biosensor

Endotoxin is well established as a main reason for endoxemia and organs failure, which are severely harmful to human health. So far, much more attention has been paid to develop a efficient and sensitive detection method with high specificity. Because of the superior efficiency and sensitivity, easy to automation and miniaturization, biosensors which is confronted with substantial development space is playing an increasingly important role in the field of endotoxin detection. In this paper, the detection methods of endotoxin in recent years were introduced briefly, and then paied special emphasis in summarizing the optical and electrochemical biosensors applied in endotoxin detection. The challenges and development prospects of endotoxin detection via biosensors are also reviewed.