| 肟醚-酰胺衍生物的合成与生物活性研究 |
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| 引用本文： | 程华,刘兴平,魏振中,凌立志,刘洋,胡春华,杨光富,柳爱平.肟醚-酰胺衍生物的合成与生物活性研究[J].化学通报,2006,69(8):635-638. |
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| 作者姓名： | 程华 刘兴平 魏振中 凌立志 刘洋 胡春华 杨光富 柳爱平 |
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| 作者单位： | 华中师范大学有机合成研究所 武汉430079(程华，魏振中，刘洋，胡春华，杨光富)，湖南化工研究院 长沙410007(刘兴平，柳爱平)，湖南师范大学化学化工系 长沙410081(凌立志) |
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| 基金项目： | 国家科技攻关计划;国家自然科学基金;湖南省自然科学基金 |
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| 摘 要： | 为了寻找高效、低毒的新农药,采用活性结构拼接法设计并合成了12个新型肟醚-酰胺类化合物,其结构均经1HNMR、IR、LC/MS及元素分析确证。初步生物活性测定结果显示,部分化合物具有明显的杀菌活性,其中化合物3a和3h在500mg/L的浓度下对小麦白粉病菌的盆栽活性均达80%以上。
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| 关 键 词： | 肟醚 酰胺 合成 生物活性 |
| 收稿时间： | 2005-10-08 |
| 修稿时间： | 2005-10-082006-02-26 |
Synthesis and Activity of Novel Oxime ether-acylamides |
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| Cheng Hua,Liu Xingping,Wei Zhenzhong,Ling Lizhi,Liu Yang,Hu Chunhua,Yang Guangfu,Liu Aiping.Synthesis and Activity of Novel Oxime ether-acylamides[J].Chemistry,2006,69(8):635-638. |
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| Authors: | Cheng Hua Liu Xingping Wei Zhenzhong Ling Lizhi Liu Yang Hu Chunhua Yang Guangfu Liu Aiping |
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| Institution: | 1.Institute of Organic Synthesis, Central China Normal University, Wuhan 430079 ; 2.Hunan Research Institute of Chemical Industry, Changsha 410007; 3.College of Chemistry and Chemical Engineering ,Hunan Normal University, Changsha 410081 |
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| Abstract: | In an attempt to find new pesticide with high activity and low toxicity, twelve novel oxime ether-acylamides were designed and synthesized according to bioisoster principle. All compounds were confirmed by I H NMR, IR ,LC/MS and element analysis. The results of preliminary bioassay showed that some compounds possessed evident fungicidal activity, 3a and 3h showed more than 80% fungicidal activity against Erysiphe graminis at 500mg/L. |
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| Keywords: | Oxime ether Acylamides Synthesis Biological activity |
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