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| 姜黄素与DNA相互作用的电化学性质 | |
| 引用本文： | 张亚锋,吴萍,林新华.姜黄素与DNA相互作用的电化学性质[J].化学研究,2009,20(1):37-39. |
| 作者姓名： | 张亚锋 吴萍 林新华 |
| 作者单位： | 1. 西安市药品检验所,陕西,西安,710075 2. 常州市人民医院,江苏,常州,213003 3. 福建医科大学,药学院,福建,福州,310004 |
| 摘 要： | 采用循环伏安法和差示脉冲伏安法,研究了姜黄素在DNA修饰玻碳电极上与DNA的相互作用.结果表明,姜黄素与DNA之间发生嵌插作用,形成了两种化合物DNA-2curcumin和DNA-curcumin,两者的表观结合常数分别为2.34×10^5L/mol和1.48 L/mol. |
| 关 键 词： | 姜黄素 小牛胸腺DNA 循环伏安法 差示脉冲伏安法 DNA修饰玻碳电极 |
Electrochemical Studies of Interaction Between Curcumin and DNA |
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| ZHANG Ya-feng,WU Ping,LIN Xin-hua.Electrochemical Studies of Interaction Between Curcumin and DNA[J].Chemical Research,2009,20(1):37-39. | |
| Authors: | ZHANG Ya-feng WU Ping LIN Xin-hua |
| Institution: | ZHANG Ya-feng, WU Ping, LIN Xin-hua ( 1. Xi＇an Institute for Drug Control, Xi＇an 710054, Shaanxi, China; 2. Changzhou People Hospital, Changzhou 213(103, Jangsu, China; 3. College of Pharmaceutical, Fujian Medical University, Fuzhou 350004, Fujian, China) |
| Abstract: | The interaction between curcumin and DNA were investigated by means of cyclic voltammetry and differential pulse voltammetry with DNA-modified glassy carbon electrodes.The results show that the interaction mode is intercalation at pH 4.0 tris-HCl buffer.Two kinds complexes of curcumin and DNA,DNA-2curcumin and DNA-curcumin,are formed with binding constants of 2.34×105 L/ mol and 1.48 L/ mol,respectively. |
| Keywords: | curcumin calf thymus DNA cyclic voltammetry differential pulse voltammetry DNA-modified glassy carbon electrode |
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