| 流动注射化学发光法测定头孢噻肟钠 |
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| 引用本文： | 王珏,屈建莹,陈文静,王金中.流动注射化学发光法测定头孢噻肟钠[J].化学研究,2010,21(4):84-86. |
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| 作者姓名： | 王珏 屈建莹 陈文静 王金中 |
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| 作者单位： | 河南大学,化学化工学院,环境与分析科学研究所,河南,开封,475004 |
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| 基金项目： | 河南省教育厅自然科学基金资助项目 |
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| 摘 要： | 基于在碱性介质中头孢噻肟钠对鲁米诺-K3Fe(CN)6化学发光体系的增强作用,建立了流动注射化学发光测定头孢噻肟钠的新方法.头孢噻肟钠的质量浓度与化学发光强度的变化在2.4～30 mg/L和60～300 mg/L范围内呈良好的线性关系,检出限为0.63 mg/L,对浓度为30 mg/L的头孢噻肟钠进行9次平行测定,相对标准偏差(RSD)为1.0%.该法简便、快速、可靠,将其用于头孢噻肟钠针剂的测定,结果令人满意.
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| 关 键 词： | 化学发光 流动注射 头孢噻肟钠 |
Determination of Cefotaxime Sodium by Flow InjectionChemiluminescence |
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| WANG Jue,QU Jian-ying,CHEN Wen-jing,WANG Jin-zhong.Determination of Cefotaxime Sodium by Flow InjectionChemiluminescence[J].Chemical Research,2010,21(4):84-86. |
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| Authors: | WANG Jue QU Jian-ying CHEN Wen-jing WANG Jin-zhong |
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| Institution: | (Institute of Environmental and Analytical Science,College of Chemistry and Chemical Engineering,Henan University,Kaifeng 475004,Henan,China) |
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| Abstract: | A new method for determination of cefotaxime sodium has been established by using flow injection chemiluminescence analysis,based on the fact that cefotaxime sodium can greatly enhance the emission intensity of the chemiluminescence reaction between K3Fe（CN）6 and luminol in alkaline medium.The relative chemiluminescence intensity is proportional to cefotaxime sodium concentration over a range of 2.4～30.0 mg/L and 60.0～300.0 mg/L,and detection limit of 0.63 mg/L is reached.Results of 9 times of parallel tests indicate that 30 mg/L of cefotaxime sodium can be determined at a relative standard deviation（RSD） of 1.0%.The method,being simple,rapid and reliable,can be satisfactorily used to determine cefotaxime sodium injection. |
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| Keywords: | chemiluminescence flow injection cefotaxime sodium |
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