| N-茄呢基-N,N′-二芳基乙二胺衍生物的合成与生理活性(英文) |
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| 引用本文： | 曹玉辉,周大鹏,杜钢军,乔爱红,赵瑾,王超杰.N-茄呢基-N,N′-二芳基乙二胺衍生物的合成与生理活性(英文)[J].化学研究,2006(2). |
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| 作者姓名： | 曹玉辉 周大鹏 杜钢军 乔爱红 赵瑾 王超杰 |
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| 作者单位： | 河南大学化学化工学院 河南开封475001 |
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| 基金项目： | SupportedbyNationalNaturalScienceFoundationofChina(20472016),andHenanNaturalScienceFoundations(0311020900,512001300) |
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| 摘 要： | 以乙二胺,芳香醛和相应的卤代物为原料合成了N-茄呢基-N,N′-二(3,4-二甲氧基苄基)乙二胺(SBD-乙二胺)及三个新的衍生物.对L1210和CHO细胞初步的体外活性测试表明在SBD-乙二胺的仲氮上引入第四个取代基后,生成的衍生物对所测细胞的抑制活性提高,但对长春新碱的增效作用减弱.
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| 关 键 词： | SDB-乙二胺 茄呢醇衍生物 合成 生理活性 |
Synthesis and Bioactivity of N-Solanesyl-N,N′-bisaryl-ethylenediamine Derivatives |
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| CAO Yu-hui,ZHOU Da-peng,DU Gang-jun,QIAO Ai-hong,ZHAO Jin,WANG Chao-jie.Synthesis and Bioactivity of N-Solanesyl-N,N′-bisaryl-ethylenediamine Derivatives[J].Chemical Research,2006(2). |
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| Authors: | CAO Yu-hui ZHOU Da-peng DU Gang-jun QIAO Ai-hong ZHAO Jin WANG Chao-jie |
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| Institution: | CAO Yu-hui,ZHOU Da-peng,DU Gang-jun,QIAO Ai-hong,ZHAO Jin,WANG Chao-jie~* |
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| Abstract: | N-Solanesyl-N,N′-bis(3,4-dimethoxybenzyl)ethylenediamine(SDB-ethylenediamine) and its three close analogues were synthesized using ethylenediamine,corresponding aromatic aldehydes and halides.The preliminary in vitro tests revealed that after the fourth group was introduced on the secondary nitrogen of SDB-ethylenediamine,the cytotoxicity of resulted analogues was increased and the synergism with vincristine was reduced for both L1210 and CHO cells. |
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| Keywords: | SDB-ethylenediamine solanesyl derivatives synthesis bioactivity |
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