| 环戊噻嗪的合成工艺改进 |
| |
| 引用本文： | 曹金,张洪强,韩静.环戊噻嗪的合成工艺改进[J].化学研究,2011(5):38-40. |
| |
| 作者姓名： | 曹金 张洪强 韩静 |
| |
| 作者单位： | 沈阳药科大学制药工程学院; |
| |
| 摘 要： | 以溴代环戊烷和丙二酸二乙酯为起始原料,经缩合、水解、脱羧、还原、氧化、环合六个步骤合成了目标化合物环戊噻嗪;所得产物结构经核磁共振氢谱和质谱确证,产物纯度经高效液相色谱(HPLC)归一化法测定.结果表明,目标产物总收率可达25.5%,纯度为99.4%;经过改进的工艺条件稳定,操作简便,收率明显提高,适合于工业化生产.
|
| 关 键 词： | 环戊噻嗪 环戊基乙醛 合成 工艺 |
Improvement for synthesis process of cyclopenthiazide |
| |
| CAO Jin,ZHANG Hong-qiang,HAN Jing.Improvement for synthesis process of cyclopenthiazide[J].Chemical Research,2011(5):38-40. |
| |
| Authors: | CAO Jin ZHANG Hong-qiang HAN Jing |
| |
| Institution: | CAO Jin,ZHANG Hong-qiang,HAN Jing~* (School of Pharmaceutical Engineering,Shenyang Pharmaceutical University,Shenyang 110016,Liaoning,China) |
| |
| Abstract: | Cyclopenthiazide was synthesized from cyclopentyl bromide and diethyl malonate by condensation,alkaline hydrolysis,decarboxylation,reduction,oxidation,and cyclization reaction. Chemical structure of the product was comfirmed by nuclear magnetic resonance spectroscopy (~1H NMR) and mass spectrometry(MS),and its purity was determined based on normalization of high-performance liquid chromatography(HPLC).It was found that target product was obtained at a total yield of 25.5%,and it purity was as much as 99.4%.... |
| |
| Keywords: | cyclopenthiazide cyclopentylacetaldehyde synthesis process |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
