脯氨酸催化的不对称Aldol反应的研究进展

不对称合成是手性药物制备的核心环节,A ldol反应是重要的形成C—C键的反应之一,在全合成中有广泛应用.脯氨酸的两个异构体均价廉易得,作为一个非金属不对称催化试剂,它催化的不对称A ldol反应立体选择性高,有很好的应用前景.本文就近二十年来脯氨酸催化A ldol反应的机理,溶剂效应,最新进展三方面进行了介绍.

Advance of Asymmetric Aldol Reactions Catalyzed by Proline

The Aldol reaction is an exceptionally useful strategic C-C bond-forming reaction for the stereoselective construction of cyclic and acyclic molecules. The synthetic value of the Aldol reactions has been proven by their application in the total synthesis of natural products. The advantages of proline based aldolisation reaction are that the methodology is metal free and that both enantiomers of the catalyst are cheap and easily available. Proline catalysed aldolisation reaction shows both high yields and stereoselectivity. The catalytic enantioselective version of this reaction has received considerable attention in recent years.