两亲性类树枝状聚合物的合成与药物控释 |
| |
引用本文: | 王帅鹏,;宋晓婉,;冯晓双,;陈鹏,;钱家盛,;夏茹,;苗继斌.两亲性类树枝状聚合物的合成与药物控释[J].化学物理学报(中文版),2014(5):587-592. |
| |
作者姓名: | 王帅鹏 ;宋晓婉 ;冯晓双 ;陈鹏 ;钱家盛 ;夏茹 ;苗继斌 |
| |
作者单位: | [1]安徽大学化学化工学院,安徽省高分子绿色材料重点实验室,合肥230601; [2]阿卜杜拉国王科技大学物理科学工程部,图瓦23955-6900 |
| |
摘 要: | 结合阴离子开环聚合方法合成了内壳为聚(乙氧基乙基缩水甘油醚),外层为聚环氧乙烷的两亲性类树枝状嵌段共聚物PEEGE-G2-b-PEO(OH)12. 使用核磁共振氢谱以及凝胶渗透色谱等表征了中间产物和目标产物. 选择阿霉素作为实验药物,研究了该聚合物的载药和控释行为. 聚合物的载药率和包覆效率分别为13.07%和45.75%,体外释放试验表现为持续性的释放,并受到释放介质pH影响.
|
关 键 词: | 阴离子开环聚合 活性聚合 类树枝状聚合物 两亲性嵌段聚合物 药物缓释 |
Synthesis of an Amphiphilic Dendrimer-Like Block Copolymer and Its Application on Drug Delivery |
| |
Institution: | Shuai-peng Wang, Xiao-wan Song, Xiao-shuang Feng, Peng Chen, Jia-sheng Qian, Ru Xia, Ji-bin Miao( a. School of Chemistry and Chemical Engineering, Anhui University, Key Laboratory of Environment- friendly Polymer Materials of Anhui Province, Hefei 230501, China ;b. Division of Physical Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal, 23955-5900, Saudi Arabia) |
| |
Abstract: | Dendrimer-like amphiphilic copolymer is a kind of three-dimensional spherical structure polymer. An amphiphilic dendrimer-like diblock copolymer, PEEGE-G2-b-PEO(OH)12, constituted of a hydrophobic poly(ethoxyethyl glycidol ether) inner core and a hydrophilic poly(ethylene oxide) outer layer, has been successfully synthesized by the living anionic ring-opening polymerization method. The intermediates and targeted products were charac-terized with 1H NMR spectroscopy and gel permeation chromatography. The application on drug delivery of dendrimer-like diblock copolymer PEEGE-G2-b-PEO(OH)12 using DOX as a model drug was also studied. The drug loading content and encapsulation e ciency were found at 13.07% and 45.75%, respectively. In vitro release experiment results indicated that the drug-loaded micelles exhibited a sustained release behavior under acidic media. |
| |
Keywords: | Anionic ring opening polymerization Living polyinerization Dendrimer-likecopolymer Amphiphilic diblock copolymer Drug delivery |
本文献已被 维普 等数据库收录! |
|