| 不同激发波长下ZnPcSP的光敏化能力和抗癌活性 |
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| 引用本文： | 黄剑东,刘尔生,杨素苓,欧阳瑞珍,陈耐生,黄金陵,黄自强,孙建成,许建华.不同激发波长下ZnPcSP的光敏化能力和抗癌活性[J].物理化学学报,1997,13(3):247-251. |
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| 作者姓名： | 黄剑东 刘尔生 杨素苓 欧阳瑞珍 陈耐生 黄金陵 黄自强 孙建成 许建华 |
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| 作者单位： | Department of Chemistry,Institute of Functional Materials,Fuzhou University,Fuzhou 350002,Cancer Pharmacology Research Section,Fujian Medical University,Fuzhou 350004 |
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| 摘 要： | 研究了激发光的波长对金属酞菁配合物ＺｎＰｃＳＰ光敏化产生Ｏ２的能力和光动力癌作用的影响，结果表明，激发波长对ＺｎＰｃＳＰ配合物光敏化产生Ｏ２的能力和光动力抗癌作用的影响显示了同样的规律性，波长为６７０ｎｍ的光具有较佳的激发效率，研究结果同时说明ＺｎＰｃＳＰ在光动力治癌中的主要光敏反应机制可能是产生Ｏ２的Ⅱ型反应机制。
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| 关 键 词： | 锌酞菁配合物 光动力治癌 光敏化反应 单重态氧 |
| 收稿时间： | 1996-05-21 |
| 修稿时间： | 1996-12-03 |
The Ability of Photosensitization and Anti-cancer of ZnPcSP under Different Exciting Wavelength |
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| Huang Jian-Dong,Liu Er-Sheng,Yang Su-Ling,Ouyang Rui-Zhen,Chen Nai-Sheng,Huang Jin-Ling,Huang Zi-Qiang,Sun Jian-Cheng,Xu Jian-Hua.The Ability of Photosensitization and Anti-cancer of ZnPcSP under Different Exciting Wavelength[J].Acta Physico-Chimica Sinica,1997,13(3):247-251. |
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| Authors: | Huang Jian-Dong Liu Er-Sheng Yang Su-Ling Ouyang Rui-Zhen Chen Nai-Sheng Huang Jin-Ling Huang Zi-Qiang Sun Jian-Cheng Xu Jian-Hua |
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| Institution: | Department of Chemistry,Institute of Functional Materials,Fuzhou University,Fuzhou 350002|Cancer Pharmacology Research Section,Fujian Medical University,Fuzhou 350004 |
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| Abstract: | The effect of wavelength of exciting light upon the ability of photogenerating singlet oxygen (1O2) and of killing cancer cells of ZnPcSP were studied. The results show that the effect on the ability of photogenerating 1O2 and the ability of killing cancer cells has the same tendency, i.e., the light of 670nm possesses the best exciting efficency. The result also suggests that type Ⅱreaction of producing 1O2 is probably the main photosensitive type in PDT of ZnPcSP. |
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| Keywords: | Zinc phthalocyanine Photodynamic therapy of cancer Photosensitive reaction Singlet oxygen |
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