| 低同源性蛋白质结构预测 |
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| 引用本文： | 倪立生,毛凤楼,韩玉真,来鲁华.低同源性蛋白质结构预测[J].物理化学学报,2001,17(5):389-392. |
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| 作者姓名： | 倪立生 毛凤楼 韩玉真 来鲁华 |
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| 作者单位： | College of Chemistry of Molecular Engineering,Institute of Physical Chemistry,Peking University,State Key Laboratory of Structural Studies for Stable and Unstable Species,Beijing 100871 |
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| 基金项目： | 国家自然科学基金(29525306)、 863和北京科委资助项目 |
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| 摘 要： | 基因组计划在实施产生了大量的DNA序列信息，如何有效地利用这些信息来研究基因的产物－蛋白质的结构与功能成为引入注目的研究领域，同源蛋白质结构预测及蛋白质折工识别是在基因组水平上进行蛋白质结构预测的有效方法，酵母基因组中约有50％的基因可以通过这类方法来确定其表面产物蛋白质的结构1]，但是目前所采用的方法在低同源性蛋白质的结构预测方面尚存在较大困难。
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| 关 键 词： | 蛋白质结构预测 折叠模式识别 低同源性 收敛进化 基因组 |
| 收稿时间： | 2001-01-12 |
| 修稿时间： | 2001年1月12日 |
Low Homologous Protein Structure Prediction |
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| Ni Li-Sheng,Mao Feng-Lou,HAN Yu-zhen,Lai Lu-Hua.Low Homologous Protein Structure Prediction[J].Acta Physico-Chimica Sinica,2001,17(5):389-392. |
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| Authors: | Ni Li-Sheng Mao Feng-Lou HAN Yu-zhen Lai Lu-Hua |
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| Institution: | College of Chemistry of Molecular Engineering,Institute of Physical Chemistry,Peking University,State Key Laboratory of Structural Studies for Stable and Unstable Species,Beijing 100871 |
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| Abstract: | The development of human genome project calls for more rapid and accurate protein structure prediction method to assign the structure and function of gene products. Threading has been proved to be successful in protein fold assignment,although difficulties remain for low homologous sequences. We have developed a method for solving the sequence rearrangement problem in threading. By reshuffling secondary elements,protein structures with the same spatial arrangement of secondary structures but different connections can be predicted. This method has been proved to be useful in fold recognition for proteins of different evolutionary origin and converge to the same fold. |
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| Keywords: | Protein structure prediction Fold recognition Low homology Convergent evolution Genome |
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