| RuCl_2[(S)-P-Phos]-[(S)-DAIPEN]催化芳香酮的不对称加氢反应 |
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| 引用本文： | 姜和,王金波,熊伟,贾云,秦瑞香,刘德蓉,陈华.RuCl_2[(S)-P-Phos]-[(S)-DAIPEN]催化芳香酮的不对称加氢反应[J].物理化学学报,2010,26(3). |
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| 作者姓名： | 姜和 王金波 熊伟 贾云 秦瑞香 刘德蓉 陈华 |
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| 作者单位： | 1. 重庆科技学院化学化工学院,重庆,401331
2. 四川大学化学学院,绿色化学及技术教育部重点实验室,成都,610064 |
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| 基金项目： | 重庆市教委基金，教育部"春晖计划" |
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| 摘 要： | 研究了钌-双膦-二胺配合物催化剂RuC1_2(S)-P-Phos]-(S)-DAIPEN]P-Phos:2,2',6,6'-四甲氧基-4,4'-双(二苯基膦基)-3,3'.二吡啶,DA肫N:1,1.二(4.甲氧苯基).2.异丙基.1,2.乙二胺]催化芳香酮不对称加氢反应的性能,考察了不同的碱、叔丁醇钾浓度、反应溶剂、底物/催化剂摩尔比等因素对反应活性和对映选择性的影响.在苯乙酮、叔丁醇钾、催化剂的摩尔比为1000:20:1,氢气压力为2 MPa,反应温度为30℃时,苯乙酮的转化率和α-苯乙醇的对映选择性(ee)分别达到了100%和88.5%,2'-溴苯乙醇的ee值町达97.1%.
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| 关 键 词： | 不对称加氢 钌膦配合物 手性二胺 芳香酮 |
Asymmetric Hydrogenation of Aromatic Ketones Catalyzed by RuCl_2[(S)-P-Phos]-[(S)-DAIPEN] |
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| JIANG He,WANG Jin-Bo,XIONG Wei,JIA Yun,QIN Rui-Xiang,LIU De-Rong,CHEN Hua.Asymmetric Hydrogenation of Aromatic Ketones Catalyzed by RuCl_2[(S)-P-Phos]-[(S)-DAIPEN][J].Acta Physico-Chimica Sinica,2010,26(3). |
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| Authors: | JIANG He WANG Jin-Bo XIONG Wei JIA Yun QIN Rui-Xiang LIU De-Rong CHEN Hua |
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| Institution: | JIANG He1 WANG Jin-Bo1,XIONG Wei1 JIA Yun1 QIN Rui-Xiang1 LIU De-Rong1 CHEN Hua2,(1College of Chemistry & Chemical Engineering,Chongqing University of Science , Technology,Chongqing 401331,P.R.China,2Key Laboratory of Green Chemistry , Technology,Ministry of Education,College of Chemistry,Sichuan University,Chengdu 610064,P.R.China) |
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| Abstract: | A ruthenium phosphine diamine complex RuCl2(S)-P-Phos]-(S)-DAIPEN] P-Phos:2,2',6,6'-tetramethoxy4,4'-bis(diphenylphosphino)-3,3'-bipyridine,DAIPEN:1,1'-di(4-anisyl)-2-iopropyl-1,2-ethylenediamine] for the asymmetric hydrogenation of aromatic ketones has been studied.The influences of different bases,(CH3)3COK concentration,organic solvent,and molar ratio of substrate to catalyst on activity and enantioselectivity were investigated.Under the following optimum conditions:n(ketone):n(KOH):n(catalyst)=1000:2... |
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| Keywords: | Asymmetric hydrogenation Ruthenium-phosphine complex Chiral diamine Aromatic ketones |
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