首页 | 本学科首页   官方微博 | 高级检索  
     检索      

载药微乳液相行为的研究
引用本文:陆杨燕,夏强,夏勇,马全红,顾宁.载药微乳液相行为的研究[J].物理化学学报,2005,21(1):98-101.
作者姓名:陆杨燕  夏强  夏勇  马全红  顾宁
作者单位:Research Center for Nano-scale Science and Technology, Key Laboratory of Molecular and Biomolecular Electronics, Ministry of Education, Southeast University; Department of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096
基金项目:江苏省自然科学基金创新人才项目(BK2002404) 江苏省计划发展委员会(7607038009)资助~~
摘    要:提出了一种基于相图研究实现纳米药物载体可控制备的方法.采用微乳液控温相图绘制装置绘制了硬脂酸聚烃氧(40)酯(S-40)/聚氧乙烯聚氧丙烯醚嵌段共聚物(F-68)/单硬脂酸甘油酯(GMS)/水体系的拟三元相图,基于电导率测定值确定了微乳液的结构(W/O、双连续相和O/W),该体系同时存在液晶区域.乳化剂S-40/F-68的质量比为7:3.研究了脂溶性药物维甲酸(RA)对微乳液相行为的影响,结果表明RA的加入对微乳液的相行为影响较小.基于相图研究结果制备了维甲酸固体脂质纳米粒(RA-SLN),亚微米粒度分析仪(PCS)测定的平均粒径和透射电镜测试都表明RA-SLN为10 nm左右的球状粒子.

关 键 词:微乳液  相行为  固体脂质纳米粒  维甲酸  
收稿时间:2004-06-24
修稿时间:2004-09-07

Studies on the Phase Behaviors of Drug-loading Microemulsions
LU,Yang-Yan.Studies on the Phase Behaviors of Drug-loading Microemulsions[J].Acta Physico-Chimica Sinica,2005,21(1):98-101.
Authors:LU  Yang-Yan
Institution:Research Center for Nano-scale Science and Technology, Key Laboratory of Molecular and Biomolecular Electronics, Ministry of Education, Southeast University; Department of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096
Abstract:A new method was presented for controllable preparation of nanoscale drug carriers based on the phase behaviors of microemulsions. The pseudoternary phase diagrams for the system polyoxyethylene (40)stearate (S-40)/polyoxyethylene-polyoxypropylene (F-68)/Glycerol monostearate (GMS)/water were obtained at 60 ℃ using home-made apparatus with temperature control.Different structures of microemulsion (W/O,B.C.and O/W) were distinguished by the conductivity measurement, and liquid crystal region was found to be in existence. The mass ratio of S-40 and F-68 was selected to be 7 ∶3. It was concluded that the introduce of retinoic acid (RA) has little influence on the phase behavior of drug-loading microemulsions. Solid lipid nanoparticle (SLN) of retinoic acid was prepared based on the phase behavior results. The mean particle size of RA-SLN determined by PCS is about 10 nm, and TEM images indicate that particles of RA-SLN are spherical with a size about 10 nm. The study on the phase behaviors of drug-loading microemulsions has been proved to be very significative for the controllable preparation of SLN.
Keywords:Microemulsions  Phase behavior  Solid lipid nanoparticle  Retinoic acid
本文献已被 CNKI 维普 万方数据 等数据库收录!
点击此处可从《物理化学学报》浏览原始摘要信息
点击此处可从《物理化学学报》下载免费的PDF全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号