| 5-氟尿嘧啶卟啉化合物的合成和光谱性质 |
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| 引用本文： | 徐四川,张慧娟,孙照勇,冯娟,艾希成,张启元,张兴康,刘彦钦,韩士田.5-氟尿嘧啶卟啉化合物的合成和光谱性质[J].物理化学学报,2001,17(10):879-886. |
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| 作者姓名： | 徐四川 张慧娟 孙照勇 冯娟 艾希成 张启元 张兴康 刘彦钦 韩士田 |
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| 作者单位： | State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Molecular Science Center, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080;Department of Chemistry, Hebei Normal University, Shijiazhuang 050091 |
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| 基金项目： | 国家自然学基金(39890390,29733100)和河北省自然科学基金(299194)资助项目性项目(KJCX2-H2), |
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| 摘 要： | 首次合成并用元素分析、红外光谱、核磁和质谱等表征了6种新的5 氟尿嘧啶卟啉化合物. 对其紫外吸收、荧光性质和荧光寿命进行了研究，并与未修饰卟啉化合物光谱性质进行了比较. 5 氟尿嘧啶卟啉化合物荧光寿命为7 ns，受环境取代基和溶剂的影响较小.
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| 关 键 词： | 5-氟尿嘧啶 卟啉 荧光寿命 单光子计数 |
| 收稿时间： | 2001-04-16 |
| 修稿时间： | 2001年4月16日 |
Synthesis and Spectroscopy Characteristics of 5-fluorouracil Porphyrin Compounds |
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| Xu Si-Chuan,Zhang Hui-Juan,Sun Zhao-Yong,Feng Juan,Ai Xi-Cheng,Zhang Qi-Yuan,Zhang Xing-Kang.Synthesis and Spectroscopy Characteristics of 5-fluorouracil Porphyrin Compounds[J].Acta Physico-Chimica Sinica,2001,17(10):879-886. |
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| Authors: | Xu Si-Chuan Zhang Hui-Juan Sun Zhao-Yong Feng Juan Ai Xi-Cheng Zhang Qi-Yuan Zhang Xing-Kang |
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| Institution: | State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Molecular Science Center, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080;Department of Chemistry, Hebei Normal University, Shijiazhuang 050091 |
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| Abstract: | fluorouracil porphyrin compounds are a new type of potential antitumor drugs. Six new 5-fluorouracil porphyrin compounds were synthesized first and characterized by means of elemental analysis, IR.HNMR and MS. The six 5-fluorouracil porphyrin compounds were studied by absorption spectra, steady-state fluorescence spectroscopy and time-resolved single photon measurement, comparing with their primary porphyrin compounds. The 5-fluorouracil porphyrin compounds with plentiful excited states and fluorescence lifetime of 7 ns are little influenced by substituents and solvents, which may be advantageously used to make singlet oxygen radical. |
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| Keywords: | fluorouracil Porphyrin Fluorescence lifetime Single photon measurement |
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