| 生物金属与胆固醇相互作用的经验势函数计算 |
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| 引用本文： | 曹槐,谢小光.生物金属与胆固醇相互作用的经验势函数计算[J].物理化学学报,1995,11(11):1044-1047. |
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| 作者姓名： | 曹槐 谢小光 |
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| 作者单位： | Department of Chemsitry,Zhongshan University,Guangzhou 510275 |
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| 摘 要： | 流行病学调查和医学实验均证实，以胆固醇在动脉血管壁沉着、形成病灶及纤维增生使管壁变硬为特征的动脉粥样硬化（AS），与血中某些金属元素的水平密切相关＊．一些临床医学观测报道了冠心病患者血中金属元素铜、锌、铬、钢等的水平与胆固醇含量变化的关系［2－6］，以期通过改善人体内微量元素的失调来抑制AS的发生和发展．AS患者血中生物金属铜、锌、铬、锅水平与胆固醇含量有关，可能意味着两者存在某种相互作用制约关系．本文通过金属一胆固醇间、胆固醇分子间、受金属离子影响的胆固醇分子间的各种模型构造，选用恰当的经验势函数…
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| 关 键 词： | 吩噻嗪 2 3-二氯-5 6-二氰基苯醌(DDQ) 电荷转移络合物 电离势 |
| 收稿时间： | 1995-01-23 |
| 修稿时间： | 1995-04-08 |
Calculation of the Potential Function of the Interaction between Biometals and Cholesterol |
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| Cao Huai, Xie Xiaoguang.Calculation of the Potential Function of the Interaction between Biometals and Cholesterol[J].Acta Physico-Chimica Sinica,1995,11(11):1044-1047. |
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| Authors: | Cao Huai Xie Xiaoguang |
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| Institution: | Department of Chemsitry,Zhongshan University,Guangzhou 510275 |
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| Abstract: | The electron information of the molecules, cholesterol, chromium-and cuppercholesterol complexes, was calculated by CNDO/M. And, using the interaction potential function method, the intermolecular interaction energies between cholesterols, the complexes, and Cu2 , Zn2 , Cd2 , Cr3 -cholesterol complexes were obtained. Based on the interaction energy, the medical role of biometals in hypercholesterolemia concerned with arteriosclerosis were explained successfully. |
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| Keywords: | Biometals Cholesterol Interaction Arteriosclerosis |
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