| 微量量热法筛选抑菌特效药的研究 |
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| 引用本文： | 刘永军,孙海涛,南照东,毕思玮,丁养军,张洪林.微量量热法筛选抑菌特效药的研究[J].物理化学学报,1995,11(10):941-944. |
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| 作者姓名： | 刘永军 孙海涛 南照东 毕思玮 丁养军 张洪林 |
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| 作者单位： | Department of Chemistry,Qufu Normal University,Shandong Qufu 273165,Shandong Medical Science University,Shandong Jinan 250012 |
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| 摘 要： | 用微量最热计连续测定细菌代谢过程中的热显变化，可获得反映细菌代谢规律的完整的热谱图以按指数生长模型对指数生长期进行处理，可计算出细菌正常代谢的生长速率常数L’．若在培养基中加入合成药物，使细菌在药物抑制作用下生长，也可获得完整的热谱图，从而计算出在药物抑制作用下细菌的生长速率常数．本义对福氏志贺氏Zb菌和金黄色葡萄球莉在四种合成药物抑制作用下的热谱进行了测定，并计算了生长速率常数，找出了细菌生长速率常数与所用药物浓度之间的定量关系，可为筛选抑菌药物和确定用药显提供定量依据’1基本原理设细菌在代谢过…
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| 关 键 词： | 微量量热 细菌 药物抑制 |
| 收稿时间： | 1994-11-01 |
| 修稿时间： | 1995-01-28 |
Study of Sifting Specific Bacteria-inhibiting Drugs by A Microcalorimetric Method |
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| Liu Yongjun, Sun Haitao, Nan Zhaodong ,Bi Siwei, Ding Yangjun, Zhang Honglin.Study of Sifting Specific Bacteria-inhibiting Drugs by A Microcalorimetric Method[J].Acta Physico-Chimica Sinica,1995,11(10):941-944. |
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| Authors: | Liu Yongjun Sun Haitao Nan Zhaodong Bi Siwei Ding Yangjun Zhang Honglin |
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| Institution: | Department of Chemistry,Qufu Normal University,Shandong Qufu 273165|Shandong Medical Science University,Shandong Jinan 250012 |
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| Abstract: | In this paper, the bacterial growth thermograms was determinded and the fungistatic action of synthetic drugs was studied. The growth rate constants (k) at different concentration of drugs was calculated and k ~ c equations were established as well.Accordingly, a good method for sifting specific bacteria-inhibiting drugs was put forword. |
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| Keywords: | Microcalorimetric method Bacteria Fungistatic action of drug |
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