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Thermal behavior of furosemide |
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| Authors: | Rita de Cássia da Silva Felipe Silva Semaan Csaba Novák Eder Tadeu Gomes Cavalheiro |
| Institution: | 1. Instituto de Química de S?o Carlos—USP, Av. Trab. S?o-carlense 400, CP 780, S?o Carlos, SP, CEP 13560-970, Brazil 3. Departamento de Química Analítica da Universidade Federal Fluminense (GQA-UFF), Outeiro S?o Jo?o Batista, s/n, Campus do Valonguinho, Niterói, RJ, Brazil 2. Budapest University of Technology and Economics, Budapest, P.O. Box 91, 1521, Hungary |
| Abstract: | Data from theoretical, thermal, and spectroscopic methods were compared in order to map a possible mechanism for the thermal decomposition of furosemide, a diuretic compound, in solid state. TG/DTG curves suggested a two-stage decomposition process. The first product of decomposition is water (m/z = 18), released due to a dimerization resulting in the formation of an amide. Then carbon dioxide (m/z = 44), nitroxide (m/z = 30), and 2-methyl-furanyl ion (m/z = 81) are released in the second stage. The chlorine substituted benzene ring, due to the double bond conjugated system, being the last fraction to decompose. Theoretical calculations presented are in agreement with experimental results. |
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